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Groundbreaking Funding Secured: DiogenX Advances Revolutionary Regenerative Treatment for Type 1 Diabetes

DiogenX Raises €27.5M Series A Financing Led by Boehringer Ingelheim Venture Fund and Roche Venture Fund

4 mins read

Key Takeaways:

  • DiogenX successfully completes a €27.5 million ($30M) Series A financing round to advance its regenerative treatment for type 1 diabetes.
  • The lead program aims to regenerate insulin-producing beta cells, potentially becoming the first disease-modifying therapy for symptomatic type 1 diabetes.
  • Funding round attracts new investors, including Roche Venture Fund, Eli Lilly and Company, and Omnes, alongside existing investors Boehringer Ingelheim Venture Fund, JDRF T1D Fund, and AdBio partners.

Introduction

DiogenX, a biotech company focused on regenerating insulin-producing beta cells for the treatment of diabetes, announces the successful completion of a €27.5 million ($30M) Series A financing round. Led by Boehringer Ingelheim Venture Fund and Roche Venture Fund, the funding will drive the advancement of DiogenX’s groundbreaking regenerative treatment for type 1 diabetes. With the potential to become the first disease-modifying therapy for symptomatic type 1 diabetes, DiogenX’s lead program has captured the attention and support of prominent investors in the biopharmaceutical industry.

Advancing Regenerative Therapies for Type 1 Diabetes

DiogenX’s lead program focuses on regenerating pancreatic insulin-producing beta cells through the modulation of the Wnt/β-catenin signaling pathway. By leveraging a recombinant protein, the company aims to offer a first-in-class, disease-modifying therapy for type 1 diabetes. Preclinical studies have demonstrated promising results, with the prevention and reversal of diabetes observed in in vivo models. Additionally, preclinical experiments have shown a significant increase in functional insulin-producing human beta cells. With a well-tolerated long-term exposure profile, DiogenX’s approach has the potential for broad clinical utility as both a monotherapy and in combination with other therapies targeting pancreatic ß-cells.

Expansion of Investment Consortium

The Series A financing round attracted new investors, including Roche Venture Fund, Eli Lilly and Company, and Omnes. These investors join the ranks of existing supporters such as Boehringer Ingelheim Venture Fund, JDRF T1D Fund, and AdBio partners. The collaborative consortium of biopharmaceutical and diabetes leaders provides DiogenX with the necessary funds and expertise to advance their lead program through Phase 1 clinical development in patients with type 1 diabetes.

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Excitement Surrounding DiogenX’s Potential

DiogenX’s lead candidate has garnered significant attention due to its unprecedented effect on beta cell regeneration. The ability to restore a patient’s own pancreatic function without the need for surgery holds the potential for a game-changing, disease-modifying impact on the type 1 diabetes community, who currently rely on insulin therapy. Investors, such as JDRF T1D Fund, are eager to support therapies that offer innovative approaches to treating and managing type 1 diabetes, with the ultimate goal of improving the lives of individuals affected by this condition.

Supporting Innovation in Biomedical Research: Boehringer Ingelheim Venture Fund

Boehringer Ingelheim Venture Fund (BIVF), a leading investor in groundbreaking biomedical research, recognizes the potential of DiogenX’s regenerative approach to diabetes. With a focus on immuno-oncology, regenerative medicine, infectious diseases, and digital health, BIVF aims to drive significant enhancements in patient care through pioneering science and clinical translation. The partnership with DiogenX marks an important milestone in the collaboration between BIVF and DiogenX as they work towards advancing regenerative therapies for type 1 diabetes.

Commitment to Advancing Therapeutics: Roche Venture Fund

The Roche Venture Fund, as the corporate venture fund of Roche, actively invests in innovative life science companies. With a portfolio of over 60 companies globally, the fund seeks to support groundbreaking solutions in the field of healthcare. Recognizing the potential of DiogenX’s regenerative approach to diabetes, Roche Venture Fund joins the consortium of investors to contribute to the advancement of the lead program. Their expertise and access to a vast network of resources will further accelerate DiogenX’s progress.

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Venture Philanthropy for Diabetes Solutions: JDRF T1D Fund

The JDRF T1D Fund, a venture philanthropy fund, is dedicated to accelerating life-changing solutions for type 1 diabetes. By partnering with private capital, including venture capital, corporations, and foundations, the fund aims to advance therapeutics, devices, diagnostics, and vaccines for individuals living with type 1 diabetes. Their strategic investments align with JDRF’s mission to fund T1D research and focus on commercial opportunities with the potential for significant impact. The continued support of the DiogenX program reflects the fund’s commitment to revolutionizing the treatment landscape for type 1 diabetes.

Omnes: Driving Energy Transition and Innovation

Omnes, a leading private equity firm dedicated to energy transition and innovation, brings its expertise and support to DiogenX. With a strong focus on renewable energy, sustainable cities, venture capital deeptech, and co-investment, Omnes aims to partner with entrepreneurs to foster long-term partnerships. Their involvement in the Series A financing round signifies their belief in the potential of DiogenX’s regenerative approach to revolutionize the treatment of type 1 diabetes. By combining deep-tech and healthcare expertise, Omnes strengthens DiogenX’s path towards clinical development.

A Promising Future for DiogenX and Type 1 Diabetes Treatment

DiogenX’s successful completion of the Series A financing round marks a significant milestone in advancing regenerative treatments for type 1 diabetes. With the support of prominent investors such as Boehringer Ingelheim Venture Fund, Roche Venture Fund, JDRF T1D Fund, and others, DiogenX is well-positioned to progress its lead program towards Phase 1 clinical trials. The potential to regenerate insulin-producing beta cells and modify the course of diabetes offers hope for improving the lives of millions of individuals worldwide.

As DiogenX continues its mission to harness the patient’s own beta cells and increase insulin production, the future of type 1 diabetes treatment looks promising. The collaboration between leading biopharmaceutical companies, diabetes-focused organizations, and venture funds signifies the shared dedication to finding innovative solutions for this complex disease.

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The successful financing round and the expertise brought forth by the investment consortium demonstrate the confidence in DiogenX’s potential to transform the treatment landscape for type 1 diabetes. By leveraging regenerative medicine and targeting the Wnt/β-catenin signaling pathway, DiogenX is on a path to revolutionize the lives of individuals living with this chronic condition.

With further advancements in clinical development and the potential for disease-modifying therapies, DiogenX’s groundbreaking approach brings new hope to the type 1 diabetes community. As the company progresses towards its clinical development goals, the collaboration between investors, researchers, and experts in the field will continue to drive innovation and pave the way for a brighter future in the fight against type 1 diabetes.

Conclusion

DiogenX’s successful Series A financing round brings optimism and momentum to the field of type 1 diabetes treatment. With a focus on regenerating insulin-producing beta cells, their leadprogram holds the potential to become the first disease-modifying therapy for symptomatic type 1 diabetes. The participation of esteemed investors such as Boehringer Ingelheim Venture Fund, Roche Venture Fund, JDRF T1D Fund, and others reflects the confidence in DiogenX’s approach and the urgent need for innovative treatments in the diabetes space.


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